Structural genomics of protein phosphatases
نویسندگان
چکیده
منابع مشابه
Protein evolution and structural genomics
The genomic data available to computational biologists represents the product of the complex processes of evolution. In particular, the forces of mutation, duplication, and selection have acted to sculpt modern protein sequence and structure in the context of changing functional requirements. Just as crystallographers are able to determine protein structures through an analysis of X-ray diffrac...
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Protein tyrosine phosphatases (PTPs) are important targets of the H(2)O(2) that is produced during mammalian signal transduction. H(2)O(2)-mediated inactivation of PTPs also may be important in various pathophysiological conditions involving oxidative stress. Here we review the chemical and structural biology of redox-regulated PTPs. Reactions of H(2)O(2) with PTPs convert the catalytic cystein...
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ژورنال
عنوان ژورنال: Journal of Structural and Functional Genomics
سال: 2007
ISSN: 1345-711X,1570-0267
DOI: 10.1007/s10969-007-9036-1